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In vivo efficacy of top five surveyed Ghanaian herbal anti‑malarial products

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dc.contributor.author Wilmot, Dennis
dc.contributor.author Ameyaw, Elvis Ofori
dc.contributor.author Amoako‑Sakyi, Daniel
dc.contributor.author Boampong, Johnson Nyarko
dc.date.accessioned 2023-09-30T13:40:49Z
dc.date.available 2023-09-30T13:40:49Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/123456789/8789
dc.description.abstract Background: Anti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), the recommended first choice for treatment of uncomplicated malaria in the country, remains efficacious. A major issue with the use of these preparations is inadequate or unreli‑ able data on their efficacy and quality. An assessment of the potency and quality of the most popular commercial anti-malarial HPs in Ghana was, therefore, carried out. The outcome of this investigation is herein discussed preceded by a short literature review of herbal medicines in Ghana. Methods: Using a questionnaire survey of 344 individuals in parts of Ghana, five of the most frequently used HPs were identified and selected for test of their efficacy and quality. The effect of the selected compounds on Plasmo- dium berghei in vivo was assessed using standard methods. Results: All five tested HPs (HP-A, HP-B, HP-C, HP-D and HP-E) showed chemo-suppressive activity against P. berghei in vivo. However the degree of parasites inhibition is significantly lower compared to the WHO-recommended artemether–lumefantrine combination (p < 0.05, 99.9% chemosuppression/activity, 28 days survival). Using the Solo‑ mon Saker’s Test, two of the preparations were found to contain chloroquine or compounds with chemical properties like that of chloroquine. Conclusion: Popular anti-malarial HPs used in southern Ghana were found to have chemo-suppressive properties. Intentional addition of chloroquine or SCs to these preparations in order to enhance their effectiveness has serious public health concerns as it may induce cross resistance to amodiaquine, one of the partner drugs in the recom‑ mended ACT for use in Ghana. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Anti-malarial drug en_US
dc.subject Plasmodium falciparum en_US
dc.subject ICR mice en_US
dc.subject Plasmodium berghei en_US
dc.subject Chemosuppression en_US
dc.subject Herbal- preparations en_US
dc.subject In vivo en_US
dc.title In vivo efficacy of top five surveyed Ghanaian herbal anti‑malarial products en_US
dc.type Article en_US


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