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Viral Vector-Based Models of Parkinson’s Disease

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dc.contributor.author Van der Perren, Anke
dc.contributor.author Van der Perren, Anke
dc.contributor.author Van den Haute, Chris
dc.contributor.author Baekelandt, Veerle
dc.date.accessioned 2023-09-30T13:46:24Z
dc.date.available 2023-09-30T13:46:24Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/123456789/8790
dc.description.abstract In order to study the molecular pathways of Parkinson’s disease (PD) and to develop novel therapeutic strategies, scientific investigators rely on animal models. The identification of PD-associated genes has led to the development of genetic PD models as an alternative to toxin-based models. Viral vector-mediated loco-regional gene delivery provides an attractive way to express transgenes in the central nervous system. Several vector systems based on various viruses have been developed. In this chapter, we give an overview of the different viral vector systems used for targeting the CNS. Further, we describe the different viral vector-based PD models currently available based on overexpression strategies for autosomal dominant genes such as a-synuclein and LRRK2, and knockout or knockdown strategies for autosomal recessive genes, such as parkin, DJ-1, and PINK1. Models based on overexpression of a-synuclein are the most prevalent and extensively studied, and therefore the main focus of this chapter. Many efforts have been made to increase the expression levels of a-synuclein in the dopami- nergic neurons. The best a-synuclein models currently available have been developed from a combined approach using newer AAV serotypes and optimized vector constructs, production, and purification methods. These third-generation a-synuclein models show improved face and predictive validity, and therefore offer the possibility to reliably test novel therapeutics. en_US
dc.language.iso en en_US
dc.subject Animal models en_US
dc.subject Parkinson’s disease en_US
dc.subject a-Synuclein en_US
dc.title Viral Vector-Based Models of Parkinson’s Disease en_US
dc.type Article en_US


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