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Laser-Induced Autofluorescence Technique for Plasmodium falciparum Parasite Density Estimation

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dc.contributor.author Owusu-Ansah, Jerry
dc.contributor.author Eghan, Moses Jojo
dc.contributor.author Boampong, Johnson Nyarko
dc.contributor.author Buah-Bassuah, Paul
dc.date.accessioned 2023-10-02T10:40:17Z
dc.date.available 2023-10-02T10:40:17Z
dc.date.issued 2016-03-03
dc.identifier.uri http://hdl.handle.net/123456789/8795
dc.description.abstract Malaria parasites, Plasmodium falciparum (P.falciparum) infections are taking a great toll on the lives of people worldwide, especially in developing countries. Recently, haemozoin detection using optical techniques tends to provide comparable parasite densities (PDs) estimation. We conducted feasibility studies on P.falciparum infected blood (i-blood) and uninfected blood (u-blood) samples from volunteers employing laser-induced fluorescence technique for PDs estimation. Fluorescence results show high intensity in u-blood than i-blood. PeakFit analysis with Loess smoothing under Lorentzian curve shows that fluorescence peak of i-blood appears red-shifted with increasing PDs. The Lorentzian curves depict that fluorescence peak intensity ratio increases with increasing PDs in i-blood samples. This technique may be potentially applied in PDs estimation to improve malaria diagnosis. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject autofluorescence en_US
dc.subject Plasmodium falciparum en_US
dc.subject parasite density en_US
dc.subject malaria diagnosis en_US
dc.title Laser-Induced Autofluorescence Technique for Plasmodium falciparum Parasite Density Estimation en_US
dc.type Article en_US


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