Abstract:
Context: Human immunodeficiency virus (HIV) is a well-known pathogen that causes acquired
immunodeficiency syndrome (AIDS). The course of HIV infection and progression may be influ-
enced by sickle cell traits. Objectives: The aim of this study was to determine the incidence of HIV
among sickle cell patients in the Cape Coast metropolis. Methods: A cross sectional study was
conducted among patients who visited the Central Regional Hospital, Cape Coast. About 2 ml of
blood sample was drawn from each participant for sickle cell test using sodium metabisulphite solu-
tion. Sickle cell positive samples were selected and tested for the presence of HIV using Alere Deter-
mineTM HIV-1/2. Results: A total of 75 patients made up of 25 males and 50 females were enrolled.
Their age ranges between 4 to 59 years (27, 1 - 15 years; 24, 16 - 30 years; 17, 31 - 45 years; 7, 46 - 60
years). Fifteen (15) (20%) had received at least a single blood transfusion while the remaining 60
(80%) had never received blood transfusion before the study. Thirty-six patients (48.0%) were
married and the other 39 patients (52.0%) were single. Five patients (6.7%) had antibodies to HIV
whereas 70 patients (93.3%) were not with the virus. Conclusion: The incidence rate of HIV among
sickle cell trait children and the youths of Cape Coast metropolis were found to be 6.7%. This may
suggest that sickle cell traits in children and the youth may be associated with HIV transmission.
