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The Ethanolic Leaf Extract of Alchornea cordifolia (Schum. & Thonn.) Muell. Arg Inhibits the Development of Dyslipidaemia and Hyperglycaemia in Dexamethasone-Induced Diabetic Rats

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dc.contributor.author Thomford, Ama Kyeraa
dc.contributor.author Thomford, Kwesi Prah
dc.contributor.author Ayertey, Fred
dc.contributor.author Edoh, Dominic Adotei
dc.contributor.author Thomford, Kobena Amissah
dc.contributor.author Ameyaw, Elvis Ofori
dc.contributor.author Boampong, J. N.
dc.contributor.author Enimil, M.
dc.contributor.author Bioh, S.A
dc.date.accessioned 2023-10-03T18:30:41Z
dc.date.available 2023-10-03T18:30:41Z
dc.date.issued 2015-09
dc.identifier.uri http://hdl.handle.net/123456789/8973
dc.description.abstract Poor lipid and glucose regulation increases the risk for the development of major cardiovascular diseases and other organ damage. The study evaluated the serum glucose and lipid lowering effects of the 70% ( v/v) ethanolic leaf extract of Alchornea cordifolia (ALC) using the dexamethasone-induced diabetic rat model. Thirty six female Sprague-Dawley rats (180-200g; n=6) were rendered hyperglycaemic with dexamethasone (10 mg/kg, sc) once daily for 8 days except the normal control. Each group received either normal saline 0.5 ml/rat, ALC (250 mg/kg, p.o. or 500 mg/kg, p.o.), glibenclamide (5 mg/kg, p.o.) or atorvastatin (5mg/kg, p.o.) as treatment once daily for 8 days. Fasting blood glucose (FBS) readings were recorded at baseline, day 4, 6 and 9. Blood was collected for the estimation of serum triglycerides (TG), total cholesterol (TC), low density lipoproteins (LDL), very low density lipoproteins (VLDL) and high density lipoprotein (HDL) on day 9. The diabetic control group had significantly raised FBS levels (8.20 ± 1.04 mmol/l; ***p<0.001). Glibenclamide (5.20 ± 0.29; ***p<0.001) and the extracts [(ALC 250 mg/kg, p.o.; (5.35 ± 0.95 mmol/l); *p<0.05); ALC 500 mg/kg, p.o.; (5.98 ± 1.12 mmol/l); *p<0.05)] prevented an increase in FBS level. The herbal extracts also reduced the level of serum lipids of rats treated. The 70% (v/v) ethanolic leaf extract of Alchornea cordifolia has some potential for use in lipid and glucose control. en_US
dc.language.iso en en_US
dc.subject Alchornea cordifolia, en_US
dc.subject antidiabetic, en_US
dc.subject antihyperglycaemic, en_US
dc.subject antihyperlipidaemic, en_US
dc.subject herbal medicines en_US
dc.title The Ethanolic Leaf Extract of Alchornea cordifolia (Schum. & Thonn.) Muell. Arg Inhibits the Development of Dyslipidaemia and Hyperglycaemia in Dexamethasone-Induced Diabetic Rats en_US
dc.type Article en_US


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