CsrA and TnaB Coregulate Tryptophanase Activity To Promote Exotoxin-Induced Killing of Caenorhabditis elegans by Enteropathogenic Escherichia coli

Bhatt, Shantanu; Anyanful, Akwasi; Kalman, Daniel

dc.contributor.author	Bhatt, Shantanu
dc.contributor.author	Anyanful, Akwasi
dc.contributor.author	Kalman, Daniel
dc.date.accessioned	2023-10-05T18:38:45Z
dc.date.available	2023-10-05T18:38:45Z
dc.date.issued	2011-09
dc.identifier.uri	http://hdl.handle.net/123456789/9116
dc.description.abstract	Enteropathogenic Escherichia coli (EPEC) requires the tnaA-encoded enzyme tryptophanase and its sub- strate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans. Here, we demonstrate that the RNA-binding protein CsrA and the tryptophan permease TnaB coregulate tryptophanase activity, through mutually exclusive pathways, to stimulate toxin-mediated paralysis and killing of C. elegans.	en_US
dc.language.iso	en	en_US
dc.publisher	JOURNAL OF BACTERIOLOGY,	en_US
dc.title	CsrA and TnaB Coregulate Tryptophanase Activity To Promote Exotoxin-Induced Killing of Caenorhabditis elegans by Enteropathogenic Escherichia coli	en_US
dc.type	Article	en_US