Abstract:
Objective: To assess the burden of maternal malaria and HIV among pregnant women in Ghana and to determine
the risk of anemia among women with dual infection. Methods: A cross-sectional study was conducted at 4 hos-
pitals in the Sekondi-Takoradi metropolis, Ghana. The study group comprised 872 consenting pregnant women
attending prenatal care clinics. Venous blood samples were screened for malaria, HIV, and hemoglobin level.
Multivariate logistic regression analysis was performed to determine the association between malaria, HIV,
and risk of anemia. Results: In all, 34.4% of the study cohort had anemia. Multivariate logistic regression analysis
indicated that pregnant women with either malaria (odds ratio 1.99; 95% confidence interval, 1.43–2.77; P=
b 0.001) or HIV (odds ratio 1.78; 95% confidence interval, 1.13–2.80; P =0.014) had an increased risk of anemia.
In adjusted models, pregnant women co-infected with both malaria and HIV displayed twice the risk of anemia.
The adjusted odds ratio was 2.67 (95% confidence interval, 1.44–4.97; P =0.002). Conclusion: Pregnant women
infected with both malaria and HIV are twice as likely to be anemic than women with a single infection or no
infection. Measures to control malaria, HIV, and anemia during pregnancy are imperative to improve birth out-
comes in this region of Ghana.
