Antimicrobial Profile and Asymptomatic Urinary Tract Infections among Pregnant Women Attending Antenatal Clinic in Bolgatanga Regional Hospital, Ghana

Abstract

Background: Urinary tract infection (UTI) in pregnancy is associated with significant morbidity for both the mother and the baby. Proper investigation and prompt treatment are needed to prevent the serious life-threatening condition and morbidity associated with UTI in pregnant women. Aim: This study was designed to detect common uropathogens and their antibiotic susceptibility pattern among asymptomatic pregnant women attending antenatal care in the Bolgatanga Regional Hospital. Methodology: Mid-stream urine samples were collected from 200 individuals and inoculated onto cysteine lactose electrolyte deficient (CLED) agar media. Colony counts yielding bacterial growth of ≥ 105 CFU /ml was regarded as significant bacteriuria. Pure isolates of bacterial pathogens were characterized by colony morphology, Gram-stain and standard biochemical procedures. Kirby Bauer disc diffusion method was used for antimicrobial susceptibility testing of all identified isolates. Results: The overall prevalence of bacteria-associated asymptomatic UTI was 17.5%. Escherichia coli (42.9%) was the most isolated organism followed by Staphylococcus aureus (34.3%), Klebsiella pneumoniae (11.4%), Staphylococcus saprophyticoccus (5.7%) and Proteus mirabilis 2 (5.7%). Yeast cells and Schistosoma haematobium were also recorded in 2% of the women. Isolates showed significant sensitivity to commercially prepared antibiotic discs. However, higher level of resistance was recorded with tetracycline, nitrofurantoin and nalidixic acid. Conclusion: Early screening for UTI should be done for all pregnant women and those found to be infected need to be treated with appropriate antimicrobial agents to avoid complications.