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Hypotensive effect of an aqueous extract of Heliotropium indicum Linn (Boraginaceae)

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dc.contributor.author Koffuor, George Asumeng
dc.contributor.author Boye, Alex
dc.contributor.author Ameyaw, Elvis O.
dc.contributor.author Amoateng, Patrick
dc.date.accessioned 2023-10-19T11:47:32Z
dc.date.available 2023-10-19T11:47:32Z
dc.date.issued 2012-05
dc.identifier.issn 2251-0176
dc.identifier.uri http://hdl.handle.net/123456789/9715
dc.description.abstract Heliotropium indicum Linn (Boraginaceae) has been used widely in the treatment of hypertension in Ghana. This study therefore was aimed at investigating the effects of an aqueous extract of H. indicum Linn on the heart and blood pressure of some laboratory animals as a means of establishing its hypotensive effect and verifying its traditional medicinal use as an antihypertensive. The extract was applied in vitro to an isolated frog and rabbit heart to investigate its effect on the force and rate of cardiac contraction, and administered to an anaesthetized cat to establish its effect on blood pressure. The extract had a dose-dependent negative inotropic and chronotropic effect on the frog and rabbit hearts similar to that observed for acetylcholine and histamine. These effects were inhibited by atropine but not mepyramine suggesting a muscarinic-receptor mediated effect. In vivo, the H. indicum aqueous extract produced a dose-related reduction in blood pressure of the anaesthetized cat. Findings reveal that H. indicum has hypotensive effect suggesting its usefulness in the treatment/management of hypertension and other cardiovascular diseases. en_US
dc.language.iso en en_US
dc.publisher International Research Journal of Pharmacy and Pharmacology en_US
dc.subject ardiovascular disease en_US
dc.subject Chronotropic effect en_US
dc.subject Hypotensive en_US
dc.subject Inotropic effect en_US
dc.subject Heart, en_US
dc.subject Acetylcholine, en_US
dc.subject Histamine, en_US
dc.subject Muscarinic activity en_US
dc.title Hypotensive effect of an aqueous extract of Heliotropium indicum Linn (Boraginaceae) en_US
dc.type Article en_US


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