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In vivo antimalarial activity of stem bark extracts of Plumeria alba against Plasmodium berghei in imprinting control region mice

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dc.contributor.author Boampong, Johnson Nyarko
dc.contributor.author Ameyaw, Elvis Ofori
dc.contributor.author Kyei, Samuel
dc.contributor.author Aboagye, Benjamin
dc.contributor.author Asare, Kwame
dc.contributor.author Afoakwah, Richmond
dc.contributor.author Boye, Alex
dc.contributor.author Donfack, Jean Hubert
dc.date.accessioned 2023-10-19T13:30:21Z
dc.date.available 2023-10-19T13:30:21Z
dc.date.issued 2013-10-18
dc.identifier.uri http://hdl.handle.net/123456789/9740
dc.description.abstract Background: The need for new antimalarial agents with a transcriptional mode of action but fewer side effects compared with artemisinin-based combination therapy for malaria has been the preoccupation of scientists in areas where malaria is a menace. Stem bark extracts of Plumeria alba, used traditionally for the treatment of malaria in Ghana, were investigated to evaluate their prophylactic and curative antimalarial properties. Methods: The antimalarial properties of P. abla were probed using aqueous (30–300 mg/kg) and dichloromethane/methanol (30–300 mg/kg) extracts of the plant in imprinting control region mice infected with Plasmodium berghei. For the curative test, the extracts were administered to the infected mice 4 days post-infection. In the prophylactic test, the animals were pre-treated with the extracts for 3 days before challenging them with P. berghei infected erythrocytes. Results: The aqueous extract exerted significant (P , 0.05–0.001) effects on P. berghei infection, similar to artemether and lumefantrine curatively and sulfadoxine/pyrimethamine prophylac- tically. However, the dichloromethane/methanol extract reduced the parasitemia curatively (P , 0.05–0.01) but not prophylactically. Conclusion: This study provides evidence to support the antimalarial properties of stem bark extract of P. alba in mice. en_US
dc.language.iso en en_US
dc.publisher Reports in Parasitology en_US
dc.subject malaria, en_US
dc.subject parasitemia, en_US
dc.subject artemether, en_US
dc.subject lumefantrine, en_US
dc.subject sulfadoxine/pyrimethamine en_US
dc.subject Ghana en_US
dc.title In vivo antimalarial activity of stem bark extracts of Plumeria alba against Plasmodium berghei in imprinting control region mice en_US
dc.type Article en_US


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