Predictive Performance of Renal Function Equations Among Ghanaians Presenting with Chronic Kidney Disease

Abstract

This study specifically evaluate the predictive performance and accuracy of the six renal function equations in patients presenting with CKD in our community. The results of these predictive equations for 50 patients using stage of CKD and/or with serum creatinine >200 μmol L^-1 were compared with the recommended methods (4v-MDRD and CG). Another 55 subjects with similar age group and sex distributions but without kidney pathology were studied as control. The most accurate results were obtained with the reference equations (4v-MDRD and CG) with CG having a slight edge over 4v-MDRD equation. The sensitivity and specificity of the 4v-MDRD equation to detect Glomerular Filtration Rate (GFR) values < 60 mL/min/1.73 m²were 67.3 and 63.9%, respectively; that of CG was 62.9 and 71.3%, respectively. These results suggest that measurement of GFR with predictive equations might be a prudent strategy for the assessment of renal function among the CKD population.