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Entero-Hepatic Discord: Consequences for Liver Disease Pathogenesis and the Risk of Hepatocellular Carcinoma

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dc.contributor.author Boye, Alex
dc.contributor.author Mornah, Martin
dc.contributor.author Koffuor, George Asumeng
dc.contributor.author Yang, Yan
dc.date.accessioned 2023-10-24T11:09:25Z
dc.date.available 2023-10-24T11:09:25Z
dc.date.issued 2016-01-06
dc.identifier.uri http://hdl.handle.net/123456789/9944
dc.description.abstract Hepatocellular carcinoma (HCC) is one of the most debilitating malignancies of hepatic origin and does not only contribute significantly to global cancer-related mor- tality but also global disease burden. Malfunctioning and dysregulation of the entero-hepatic axis culminating from chronic ingestion of dietary and other non-specific food substances have been implicated in liver disease patho- genesis and this has the potential to increase risk of HCC. As a result, there have been increased efforts to advance understanding of the role played by the perturbed gut in liver disease and the key cell and molecular players in- volved. Luckily, growing evidence from many independ- ent studies seem to lend credence to the phenomenon of bidirectional pathogenesis of entero-hepatic diseases. This has raised hopes of finding more sensitive and specific biomarkers for prognosis and diagnosis of entero-hepatic diseases as well as identification of new therapeutic tar- gets, more specifically for therapy against major risk fac- tors (NAFLD, NASH, liver fibrosis, and cirrhosis) of HCC. This chapter takes a panoramic view of the interactions between the perturbed gut and the susceptible liver. Spe- cifically, the chapter highlights the consequences of gut dysbiosis for liver disease pathogenesis and the risk of HCC. en_US
dc.language.iso en en_US
dc.publisher Recent Advances in Hepatocellular Cancer en_US
dc.title Entero-Hepatic Discord: Consequences for Liver Disease Pathogenesis and the Risk of Hepatocellular Carcinoma en_US
dc.type Book chapter en_US


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