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Anti-inflammatory and safety assessment of Polyscias fruticosa (L.) Harms (Araliaceae) leaf extract in ovalbumin-induced asthma

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dc.contributor.author Koffuor, George Asumeng
dc.contributor.author Boye, Alex
dc.contributor.author Ofori-Amoah, Jones
dc.contributor.author Kyei, Samuel
dc.contributor.author Abokyi, Samuel
dc.contributor.author Nyarko, Raymond Appiah
dc.contributor.author Bangfu, Ruth Naalukyem
dc.date.accessioned 2023-10-24T18:34:07Z
dc.date.available 2023-10-24T18:34:07Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/123456789/9987
dc.description.abstract Background: Polyscias fruticosa is a plant used in the traditional management of asthma in Ghana. Aim: This study evaluated the anti-inflammatory property of an ethanolic leaf extract of Polyscias fruticosa and safety for use in ovalbumin-induced asthma. Methodology: The total and differential white blood cell counts, C-reactive protein level, and erythrocyte sedimentation rate were determined for blood samples obtained from Duncan Hartley guinea-pigs following sensitization (150 µg OVA + 100 mg aluminium hydroxide, I.P), OVA aerosol challenge, and treatment with 2 ml/kg normal saline, 10mg/kg prednisolone and 100, 250 or 500 mg/kg of the extract. An acute and delayed toxicity study was also conducted. Results: White blood cells and its differentials were significantly elevated (P ≤ 0.05) after OVA-induced asthma. Treatments with the extracts and prednisolone significantly reduced (P≤0.05) elevated white blood cells and its differentials. Elevated serum C-reactive protein (≥ 6.0 ± 0.00 mg/l) was reduced to within normal levels, and there was a significant decrease (P ≤ 0.01) in erythrocyte sedimentation rates in PFE and prednisolone-treated animals following OVA-induced asthma. PFE showed no significant toxic effect at lower doses (NOAEL: < 1000 mg/kg) Conclusion: The ethanolic leaf extract of Polyscias fruticosa reduces white blood cell count and i en_US
dc.language.iso en en_US
dc.publisher The Journal of Phytopharmacology en_US
dc.subject Anti-asthmatic, en_US
dc.subject White blood cells, en_US
dc.subject Ovalbumin, en_US
dc.subject Erythrocyte sedimentation rate, en_US
dc.subject C- reactive protein, en_US
dc.subject Acute en_US
dc.subject delayed toxicity test. en_US
dc.title Anti-inflammatory and safety assessment of Polyscias fruticosa (L.) Harms (Araliaceae) leaf extract in ovalbumin-induced asthma en_US
dc.type Article en_US


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