Abstract:
Background: Leaf extracts of Ficus exasperata has been used traditionally in Ghana for the management of
sprains, sore eyes, rheumatism and arthritis.
Objective: This study evaluates the scientific basis for the use of Ficus exasperata leaves in the management
of acute and chronic musculoskeletal pain
Methods: The carrageenan-kaolin-induced hyperalgesia model was used to assess acute and chronic
musculoskeletal pain using the Randall-Sellito and the grip strength tests using morphine as a reference drug.
Results: F. exasperata extract (30-300 mg kg-i) significantly and dose-dependently decreased acute skeletal
pain as well as chronic skeletal hyperalgesia in the ipsilateral and contralateral paws with maximum possible
anti-hyperalgesia effects being achieved at the highest dose.
Furthermore, it completely reversed both acute and chronic muscle hyperalgesia in a significant and dosedependent
manner.
Conclusion: These findings thus support the usefulness of Ficus exasperata leaf extracts in the management
of musculoskeletal pain.
