Effects of Hydroalcoholic leaf Extract of Ficus Exasperata Vahl (Moraceae) In Carrageenan! Kaolin-Induced Acute and Chronic Musculoskeletal Pain in Rats

Abstract

Background: Leaf extracts of Ficus exasperata has been used traditionally in Ghana for the management of sprains, sore eyes, rheumatism and arthritis. Objective: This study evaluates the scientific basis for the use of Ficus exasperata leaves in the management of acute and chronic musculoskeletal pain Methods: The carrageenan-kaolin-induced hyperalgesia model was used to assess acute and chronic musculoskeletal pain using the Randall-Sellito and the grip strength tests using morphine as a reference drug. Results: F. exasperata extract (30-300 mg kg-i) significantly and dose-dependently decreased acute skeletal pain as well as chronic skeletal hyperalgesia in the ipsilateral and contralateral paws with maximum possible anti-hyperalgesia effects being achieved at the highest dose. Furthermore, it completely reversed both acute and chronic muscle hyperalgesia in a significant and dosedependent manner. Conclusion: These findings thus support the usefulness of Ficus exasperata leaf extracts in the management of musculoskeletal pain.