University of Cape Coast Institutional Repository

Effects of Hydroalcoholic leaf Extract of Ficus Exasperata Vahl (Moraceae) In Carrageenan! Kaolin-Induced Acute and Chronic Musculoskeletal Pain in Rats

Show simple item record

dc.contributor.author Boakye-Gyasi, Eric
dc.contributor.author Abotsl, Wonder K. M.
dc.contributor.author Biney, Robert P.
dc.contributor.author Amevaw, Elvis O.
dc.contributor.author Woode, Eric
dc.date.accessioned 2022-07-07T13:56:05Z
dc.date.available 2022-07-07T13:56:05Z
dc.date.issued 2014
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8429
dc.description 12p:, ill. en_US
dc.description.abstract Background: Leaf extracts of Ficus exasperata has been used traditionally in Ghana for the management of sprains, sore eyes, rheumatism and arthritis. Objective: This study evaluates the scientific basis for the use of Ficus exasperata leaves in the management of acute and chronic musculoskeletal pain Methods: The carrageenan-kaolin-induced hyperalgesia model was used to assess acute and chronic musculoskeletal pain using the Randall-Sellito and the grip strength tests using morphine as a reference drug. Results: F. exasperata extract (30-300 mg kg-i) significantly and dose-dependently decreased acute skeletal pain as well as chronic skeletal hyperalgesia in the ipsilateral and contralateral paws with maximum possible anti-hyperalgesia effects being achieved at the highest dose. Furthermore, it completely reversed both acute and chronic muscle hyperalgesia in a significant and dosedependent manner. Conclusion: These findings thus support the usefulness of Ficus exasperata leaf extracts in the management of musculoskeletal pain. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Musculoskeletal pain en_US
dc.subject Grip strength en_US
dc.subject Hyperalgesia en_US
dc.subject Morphine en_US
dc.title Effects of Hydroalcoholic leaf Extract of Ficus Exasperata Vahl (Moraceae) In Carrageenan! Kaolin-Induced Acute and Chronic Musculoskeletal Pain in Rats en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search UCC IR


Advanced Search

Browse

My Account