Abstract:
Pseudospondias microcarpa (Anacardiaceae), the African grape tree, is used for various CNS disorders.
The neuropharmacological activities of the hydroethanolic leaf extract of Pseudospondias microcarpa
(PME) were screened in mice. In this study, the central nervous system (CNS) activity was tested in
various animal models including Irwin test, pentobarbitone-induced sleeping time, spontaneous motor
activity, rotarod test, pentylenetetrazole-induced convulsions and tail immersion test. The extract
produced sedation and analgesia in the Irwin test with an LD50 above 3000 mg kg-1. PME potentiated
pentobarbitone sleeping time and induced hepatic enzymes. It however, showed no effect on locomotor
activity or motor coordination. Furthermore, the extract blocked convulsions induced by PTZ and
showed analgesic activity in the tail withdrawal test. The present investigation suggests that PME may
act as a sedative with analgesic and anticonvulsant activity, and thus supporting its use as a sedative and
for the relief of various nervous system disorders.
