University of Cape Coast Institutional Repository

Effects of hyrdroethanolic leaf extract of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae) on the central nervous system in mice

Show simple item record

dc.contributor.author Adongo, Donatus Wewura
dc.contributor.author Mante, Priscilla Kolibea
dc.contributor.author Woode, Eric
dc.contributor.author Ameyaw, Elvis Ofori
dc.contributor.author Kukuia, Kennedy Kwami Edem
dc.date.accessioned 2023-09-29T14:51:30Z
dc.date.available 2023-09-29T14:51:30Z
dc.date.issued 2014-11
dc.identifier.uri http://hdl.handle.net/123456789/8722
dc.description.abstract Pseudospondias microcarpa (Anacardiaceae), the African grape tree, is used for various CNS disorders. The neuropharmacological activities of the hydroethanolic leaf extract of Pseudospondias microcarpa (PME) were screened in mice. In this study, the central nervous system (CNS) activity was tested in various animal models including Irwin test, pentobarbitone-induced sleeping time, spontaneous motor activity, rotarod test, pentylenetetrazole-induced convulsions and tail immersion test. The extract produced sedation and analgesia in the Irwin test with an LD50 above 3000 mg kg-1. PME potentiated pentobarbitone sleeping time and induced hepatic enzymes. It however, showed no effect on locomotor activity or motor coordination. Furthermore, the extract blocked convulsions induced by PTZ and showed analgesic activity in the tail withdrawal test. The present investigation suggests that PME may act as a sedative with analgesic and anticonvulsant activity, and thus supporting its use as a sedative and for the relief of various nervous system disorders. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Analgesia en_US
dc.subject CNS depressant en_US
dc.subject Irwin test en_US
dc.subject Pentobarbitone (PBT) en_US
dc.subject Pseudospondias microcarpa (PME) en_US
dc.title Effects of hyrdroethanolic leaf extract of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae) on the central nervous system in mice en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search UCC IR


Advanced Search

Browse

My Account