School of Allied Health Sciences: Recent submissions

Now showing items 241-260 of 454

The Role Of Herbalists In The Management Of Severe And Uncomplicated Malaria Among Children In The Shama Ahanta East And Ahanta West Districts Of Ghana

Boampong, J.N.; Acquah, S.; Opoku, S.; Amoako-Sakyi, D. (Journal of Ghana Science Association, 2011-06)

The role of herbalists in the management of malaria in Ghana is yet to be recognized despite the proliferation of antimalarial herbal products produced by the herbalists, on the Ghanaian mar- ket. This study was carried ...
The RNA-binding protein SUP-12 controls muscle- specific splicing of the ADF/cofilin pre-mRNA in C. elegans

Anyanful, Akwasi; Ono, Kanako; Johnsen, Robert C.; Ly, Hinh; Jensen, Victor; Baillie, David L.; Ono, Shoichiro (THE JOURNAL OF CELL BIOLOGY, 2004-11)

T issue-specific alternative pre-mRNA splicing is essen- tial for increasing diversity of functionally different gene products. In Caenorhabditis elegans, UNC- 60A and UNC-60B, nonmuscle and muscle isoforms of actin ...
The effects of malaria and HIV co-infection on hemoglobin levels among pregnant women in Sekondi-Takoradi, Ghana

Orish, Verner N.; Onyeabor, Onyekachi S.; Boampong, Johnson N.; Acquah, Samuel; Sanyaolu, Adekunle O.; Iriemenam, Nnaemeka C. (International Journal of Gynecology and Obstetrics, 2013)

Objective: To assess the burden of maternal malaria and HIV among pregnant women in Ghana and to determine the risk of anemia among women with dual infection. Methods: A cross-sectional study was conducted at 4 hos- pitals ...
Computational/in silico methods in drug target and lead prediction

Agamah, Francis E.; Mazandu, Gaston K.; Hassan, Radia; Bope, Christian D.; Thomford, Nicholas E.; Ghansah, Anita; Chimusa, Emile R. (Briefings in Bioinformatics, 2020)

Drug-like compounds are most of the time denied approval and use owing to the unexpected clinical side effects and cross-reactivity observed during clinical trials. These unexpected outcomes resulting in significant ...
Sero-prevalence of hepatitis B and C viral infections in Ghanaian HIV positive cohort: a consideration for their health care

Pappoe, Faustina; Hagan, Charles Kofi Oheneba; Obiri-Yeboah, Dorcas (BMC Infectious Disease, 2019)

Background: Antiretroviral therapy (ART) has significantly decreased HIV/AIDS-related morbidity and mortality. However, globally, many people living with HIV die from non-AIDS related illnesses including liver diseases ...
Promoting Undetectable Equals Untransmittable in Sub-Saharan Africa: Implication for Clinical Practice and ART Adherence

Thomford, Nicholas Ekow; Mhandire, Doreen; Dandara, Collet (International Journal of Environmental Research and Public Health, 2020)

In the last decade, reliable scientific evidence has emerged to support the concept that undetectable viral loads prevent human immunodeficiency virus (HIV). Undetectable equals untransmissible (U = U) is a simple message ...
Prevalence of severe acute rotavirus gastroenteritis and intussusceptions in Ghanaian children under 5 years of age

Enweronu-Laryea, Christabel C.; Sagoe, Kwamena W. C.; Glover-Addy, Hope; Asmah, Richard H.; Mingle, Julius A.; Armah, George E. (2012)

Introduction: Vaccination is the most effective preventive strategy against rotavirus disease. Regional differences in prevalent rotavirus genotypes may affect vaccine efficacy. Pre-vaccine surveillance for burden of ...
Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates

Adams, Tryphena; Ennuson, Nana Aba A.; Quashie, Neils B.; Futagbi, Godfred; Matrevi, Sena; Hagan, Oheneba C. K.; Abuaku, Benjamin; Koram, Kwadwo A.; Duah, Nancy O. (Biomed Central, 2018)

Background: Plasmodium falciparum delayed clearance with the use of artemisinin-based combination therapy (ACTs) has been reported in some African countries. Single nucleotide polymorphisms (SNPs) in two genes, P. falciparum ...
Prevalence of intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp-SP) use during pregnancy and other associated factors in Sekondi-Takoradi, Ghana

Orish, Verner N.; Onyeabor, Onyekachi S.; Boampong, Johnson N.; Afoakwah, Richmond; Nwaefuna, Ekene; Acquah, Samuel; Sanyaolu, Adekunle O.; Iriemenam, Nnaemeka C. (African Health Sciences, 2015-12)

Background: Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) has been adopted as policy by most countries in sub-Saharan Africa. This cross-sectional study assessed the prevalence ...
Plasmodium falciparum genetic factors rather than host factors are likely to drive resistance to ACT in Ghana

Hodoameda, Peter; Duah‑Quashie, Nancy Odurowah; Hagan, Charles Oheneba; Matrevi, Sena; Abuaku, Benjamin; Koram, Kwadwo; Quashie, Neils Ben (BMC, 2020)

Background: Artemisinin-based combination therapy (ACT) partner drugs, currently used in Ghana are lumefantrine, amodiaquine and piperaquine. Plasmodium falciparum isolates with reduced susceptibility to these partner ...
Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition

Thomford, Nicholas E.; Dzobo, Kevin; Chopera, Denis; Wonkam, Ambroise; Skelton, Michelle; Blackhurst, Dee; Chirikure, Shadreck; Dandara, Collet (Pharmaceuticals, 2015)

The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the ...
Pattern of Breast Cancer Distribution in Ghana: A Survey to Enhance Early Detection, Diagnosis, and Treatment

Ghartey, Frank Naku; Anyanful, Akwasi; Eliason, Sebastian; Adamu, Saanid Mohammed; Debrah, Samuel (International Journal of Breast Cancer, 2016)

Background. Nearly 70% of women diagnosed with breast cancer in Ghana are in advanced stages of the disease due especially to low awareness, resulting in limited treatment success and high death rate. With limited ...
Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene

Dolan-Livengood, Jennifer M.; Lewis, Taiesha; Sheth, Seema; DeZalia, Mark N.; Sherman, Melanie A.; Kalman, Lisa V.; Benian, Guy M.; Kalman, Daniel (Molecular Microbiology, 2005)

Pathogenic Escherichia coli, including enteropatho- genic E. coli (EPEC), enterohaemorrhagic E. coli (EHEC), enteroinvasive E. coli (EIEC) and enterotoxi- genic E. coli (ETEC) are major causes of food and water-borne ...
Elevated adiponectin but varied response in circulating leptin levels to falciparum malaria in type 2 diabetics and non-diabetic controls

Acquah, Samuel; Eghan Jnr, Benjamin Ackon; Boampong, Johnson Nyarko (Biomedical Journal, 2016)

Background: To investigate effects of falciparum malaria on circulating levels of leptin and adiponectin in type 2 diabetes mellitus (T2DM) and non-diabetic controls in relation to measures of adiposity. Methods: Levels ...
Increased Oxidative Stress and Inflammation Independent of Body Adiposity in Diabetic and Nondiabetic Controls in falciparum Malaria

Acquah, Samuel; Boampong, Johnson Nyarko; Eghan Jnr, Benjamin Ackon (BioMed Research International, 2016)

Information on the extent to which oxidative stress and inflammation occur in the presence of falciparum malaria and type 2 diabetes mellitus in the same individual is limited. This study sought to investigate the extent ...
Not Everyone Fits the Mold: Intratumor and Intertumor Heterogeneity and Innovative Cancer Drug Design and Development

Dzobo, Kevin; Senthebane, Dimakatso Alice; Thomford, Nicholas Ekow; Rowe, Arielle; Dandara, Collet; Parker, M. Iqbal (OMICS A Journal of Integrative Biology, 2018)

Disruptive innovations in medicine are game-changing in nature and bring about radical shifts in the way we un- derstand human diseases, their treatment, and/or prevention. Yet, disruptive innovations in cancer drug design ...
Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

Thomford, Nicholas Ekow; Senthebane, Dimakatso Alice; Rowe, Arielle; Munro, Daniella; Seele, Palesa; Maroyi, Alfred (International Journal of Molecular Sciences, 2018-05-25)

The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant ...
Lipid and Lipoprotein Levels in Type 2 Diabetes Patients Attending the Central Regional Hospital in the Cape Coast Metropolis of Ghana

Acquah, Samuel; Boampong, Johnson Nyarko; Achampong, Emmanuel K.; Setorglo, Jacob; Obiri -Yeboah, Dorcas (International Journal of Health Research, 2011-06)

Purpose: To ascertain the prevalence of dyslipidaemia in diabetics in Cape Coast. Methods: This preliminary outpatient-based cross-sectional study was conducted in 79 diabetic patients (22 males and 57 females) receiving ...
Linking Malaria To Type 2 Diabetes Mellitus: A Review

Acquah, Samuel (Journal of Ghana Science Association, 2019-06)

Malaria and diabetes continue to affect millions of people globally. Although global malaria burden is declining gradually, that of diabetes seems to be increasing. Sub-Saharan Africa with the greatest burden of malaria ...
Levels Of Serum Alanine/Aspartate Aminotransferase And Urea In Apparently Healthy Rural Community In Ghana: A Case Study In Sabin-Akrofrom And Trede In The Ashanti Region

Boampong, J.N.; Acquah, S.; Mate-Siakwa, P.; Mensah, D. Osei-Bonsu; Nyarko, A. (Journal of Ghana Science Association, 2009-06)

Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and urea levels were assessed in 27 males (mean age 32.33 yrs) and in 34 females (mean age 27.85yrs) Ghanaian ru- ral dwellers to determine the ...

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